Journal article
SARS-CoV-2-specific CD8 T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years
LC Rowntree, J Audsley, LF Allen, HA McQuilten, RR Hagen, P Chaurasia, J Petersen, DR Littler, HX Tan, L Murdiyarso, JR Habel, IJH Foo, W Zhang, ERV ten Berge, H Ganesh, P Kaewpreedee, KWK Lee, SMS Cheng, JSY Kwok, D Jayasinghe Show all
Proceedings of the National Academy of Sciences of the United States of America | Published : 2024
Abstract
Long COVID occurs in a small but important minority of patients following COVID-19, reducing quality of life and contributing to healthcare burden. Although research into underlying mechanisms is evolving, immunity is understudied. SARS-CoV-2-specific T cell responses are of key importance for viral clearance and COVID-19 recovery. However, in long COVID, the establishment and persistence of SARS-CoV-2-specific T cells are far from clear, especially beyond 12 mo postinfection and postvaccination. We defined ex vivo antigen-specific B cell and T cell responses and their T cell receptors (TCR) repertoires across 2 y postinfection in people with long COVID. Using 13 SARS-CoV-2 peptide–HLA tetra..
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Awarded by Sylvia and Charles Viertel Charitable Foundation
Funding Acknowledgements
This research included samples and data from SETREP-ID. We thank all SETREP-ID investigators and sites and all participants involved. We thank B. Scher for ethics and governance for SETREP-ID and the Australian Partnership for Preparedness Research on Infectious Disease Emergencies (APPRISE) for ongoing funding of SETREP-ID. We thank A. Rhodes, J. Chang, A. Dantanarayana, and R. Cao who contributed to the SETREP-ID biobank. SETREP-ID is supported by funding from NHMRC Centre of Research Excellence, APPRISE (ID 1116530) , Snow Medical Foundation,Jack Ma Foundation, and A2 Milk Company. We thank K. Yiu and K. Ling for Hong Kong patient sample coordination. We thank Melbourne Cytometry Platform. This work was supported by NHMRC L1 to K.K. (#1173871) , NHMRC EL1 to L.C.R. (#2026357) and T.H.O.N. (#1194036) , NHMRC EL2 to J.A.J. (#2009308) and S.A.V. (#2007929) . J.R. is supported by an ARC Laureate Fellowship. S.G. was supported by NHMRC SRF (#1159272) and Medical Research Future Fund (MRF2005654) . J.A.J. is supported by the Sylvia and Charles Viertel Charitable Foundation. This work was supported by Research Grants Council of the Hong Kong Special Administrative Region, China (#T11-712/19-N) to K.K., L.L.M.P., M.P., S.A.V., Theme-based Research Scheme of the Research Grants Council of HKSAR (#T11-705/21-N) to S.A.V., L.L.M.P., and M.P., Health and Medical Research Fund (#1903003) to D.S.C.H., MRFF Award (#1202445) to K.K., MRFF Award (#2005544) to K.K.,J.A.J.,A.K.W., S.J.K., MRFF Award (#2016062) to K.K.,T.H.O.N., L.C.R., J.A.J.,A.K.W., S.J.K., J.R., and J.A.T.